Op-brai130067 1399..1414

The effect of the novel phosphodiesterase-4 inhibitor MEM 1414 on the allergen induced responses in mild asthma

BACKGROUND Inhaled allergen challenge is a standard method to study airway responses to inflammatory provocation and evaluate the therapeutic potential of novel anti-inflammatory compounds in asthma. MEM 1414 is a novel oral PDE4 inhibitor with high affinity and selectivity creating the potential for an improved side effect profile vs non-selective PDE inhibitors. We evaluated the tolerability ...

Retraction notice for: Characteristics of liver fibrosis with different etiologies using a fully quantitative fibrosis assessment tool [Braz J Med Biol Res (2017) 50(6): e5234]

[This retracts the article doi: 10.1590/1414-431x20175234].

Fracture risk prediction using BMD and clinical risk factors in early postmenopausal women: sensitivity of the WHO FRAX tool.

The aim of this prospective study was (1) to identify significant and independent clinical risk factors (CRFs) for major osteoporotic (OP) fracture among peri- and early postmenopausal women, (2) to assess, in this population, the discriminatory capacity of FRAX and bone mineral density (BMD) for the identification of women at high risk of fracture, and (3) to assess whether adding risk factors...

Will direct laryngoscopy become an extinct skill?

Step to CEP152: uncovering a new mutation implicated in Seckel syndrome.